Yes, CAV systems can be used in buildings with multiple temperature zones. In such cases, the CAV system would be designed to condition multiple zones, each with its own set of zone dampers and reheat coils or other terminal units. This approach can be more complex than using a single-zone CAV system, but it allows for some degree of temperature control in each zone. However, VAV systems may be more suitable for buildings with multiple temperature zones, as they can provide more precise control over airflow and temperature in each zone.