When selecting a refrigerant, it’s crucial to consider the environmental impact alongside other factors such as thermodynamic properties, safety, and material compatibility. Refrigerants with low global warming potential (GWP) and ozone depletion potential (ODP) are generally preferred. However, these eco-friendly options might compromise on other selection criteria, such as energy efficiency or material compatibility. A thorough evaluation of the trade-offs between these factors is necessary to make an informed decision that balances environmental sustainability with system performance and safety.