Material compatibility is a critical consideration when selecting a refrigerant, as incompatible materials can lead to system failures, leaks, or corrosion. Refrigerants can react with system components, such as copper, aluminum, or steel, causing damage or degradation. It’s essential to evaluate the compatibility of the refrigerant with system materials, including pipes, fittings, and equipment, to ensure a safe and reliable operation. Consulting with manufacturers’ guidelines and conducting compatibility tests can help ensure that the selected refrigerant is compatible with the system’s materials.