The selection of refrigerant, brine, or oil depends on various factors, including system type, operating conditions, and environmental considerations. The Refrigerant, Brines, Oils chapter of the Carrier System Design Manual provides data to guide engineers in the application and selection of these substances. Engineers should consider factors such as refrigerant safety classification, brine freezing points, and oil viscosity to ensure safe and efficient system operation. Additionally, engineers should consult industry standards, such as ASHRAE guidelines, to ensure compliance with relevant codes and regulations.