Natural refrigerants can offer higher energy efficiency compared to HFCs, depending on the application and system design. For example, carbon dioxide-based systems can achieve higher coefficients of performance (COP) than HFC-based systems, especially at low temperatures. Ammonia-based systems can also provide higher efficiency and lower energy consumption. However, the energy efficiency of natural refrigerant-based systems depends on various factors, including system design, operating conditions, and equipment selection.