Refrigerant classifications influence system design and operation in several ways. For example, systems using CFCs or HCFCs may require additional safety features and handling procedures due to their toxicity and flammability. HFC systems, on the other hand, may require more complex compressor designs and higher operating pressures. Natural refrigerant systems may necessitate larger equipment sizes and specialized piping materials. Understanding refrigerant classifications is essential for designing and operating efficient, safe, and environmentally friendly HVAC systems.