The F-Gas Regulation, implemented by the European Union, focuses on reducing emissions of fluorinated gases, including HFCs, through a phase-down approach. The Clean Air Act, on the other hand, is a US federal law that regulates air pollutants, including ozone-depleting substances and greenhouse gases. While both regulations aim to reduce refrigerant emissions, the F-Gas Regulation is more focused on HFCs, whereas the Clean Air Act has a broader scope, covering multiple air pollutants.