What are the challenges associated with implementing natural refrigerants in HVAC systems?

Implementing natural refrigerants in HVAC systems poses several challenges, including higher upfront costs, system design modifications, and safety considerations. Natural refrigerants often require specialized equipment, training, and handling procedures due to their unique properties. Furthermore, the availability and affordability of natural refrigerant-based systems can be limited in certain regions. Careful planning, design, and installation are crucial to overcome these challenges and ensure successful implementation.