Common issues that can arise in humidification and dehumidification systems include inadequate humidification or dehumidification, incorrect sensor calibration, clogged or dirty humidification or dehumidification components, and inadequate system maintenance. Other issues can include incorrect system design, inadequate air flow, or incorrect temperature control. Regular monitoring, maintenance, and troubleshooting are essential to identify and address these issues promptly, ensuring efficient and reliable system operation.