Improper ventilation when handling flammable refrigerants can lead to the accumulation of flammable vapors, increasing the risk of explosion or fire. This can result in serious injury or death, as well as damage to equipment and property. In addition, improper ventilation can also lead to refrigerant leaks, which can cause environmental harm and contaminate soil and groundwater. Therefore, it is essential to ensure proper ventilation, including the use of exhaust fans, ventilation hoods, and explosion-proof equipment, to minimize the risks associated with flammable refrigerants.