The ozone depletion potential (ODP) of refrigerants measures their ability to deplete the Earth’s ozone layer. Refrigerants with high ODP values, such as R-22, contribute to ozone depletion and are being phased out under the Montreal Protocol. In contrast, refrigerants with low or zero ODP values, such as R-410A and R-32, are considered more environmentally friendly and are increasingly used in new HVAC systems.