HVAC system designers and operators play a crucial role in minimizing the environmental impact of refrigerants by selecting refrigerants with lower ODP and GWP values, designing systems for optimal efficiency, and implementing proper maintenance and leak detection practices. They must also ensure compliance with industry regulations and standards, such as those set by the American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE). By taking these steps, they can reduce the environmental footprint of HVAC systems and contribute to a more sustainable future.