Regulations play a significant role in driving the transition to natural refrigerants. The Montreal Protocol and its amendments aim to phase down the production and consumption of HCFCs and HFCs. The European Union’s F-Gas Regulation and similar regulations in other regions impose restrictions on the use of HFCs with high GWP. These regulations create a framework for the industry to adopt more environmentally friendly refrigerants and encourage innovation in natural refrigerant-based technologies.