When handling and selecting refrigerants, it’s essential to consider safety aspects such as toxicity, flammability, and explosivity. Refrigerants can be hazardous if not handled properly, and some may require special safety precautions or equipment. For example, refrigerants like ammonia (R-717) are toxic and require proper ventilation and protective gear when handling. It’s crucial to follow safety guidelines and regulations, such as OSHA and ASHRAE standards, to ensure a safe working environment and minimize risks associated with refrigerant handling.