The layout of an HVAC system in a house depends on the size and shape of the house, as well as the type of system being installed. Generally, the system should be designed to provide adequate air circulation and temperature control throughout the house. To do this, the system should be designed to provide air flow to all rooms, with the air intake and exhaust vents located in the appropriate places. Additionally, the system should be designed to provide adequate insulation to prevent heat loss or gain. Finally, the system should be designed to provide adequate air filtration to ensure clean air is circulated throughout the house.